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Non-Thermal Radio Frequency Stimulation of Tubulin Polymerization In Vitro: A Potential Therapy For Cancer Treatment

Open Journal of Biophysics Background:  The use  of radio frequency energy is an established technology for certain oncology therapies.  Direct inputs of radio frequency (RF) energy as thermal energy are applied to ablate tumors or catalyze secondary reactions in adjunct treatments against certain tumor types. Yet, other applications are being developed which take advantage of…

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A Feasibility Study Of The Nativis Voyager System In Patients With Recurrent Glioblastoma Multiforme (GBM): Interim Results Of First-In-Human Study

2017 ASCO Annual Meeting Abstract Background:  In this prospective, multi-center trial, patients with GBM, following recurrence after receiving standard-of-care chemotherapy and/or radiotherapy were considered for the study. Patients were treated with Voyager alone or with Voyager plus concurrent chemotherapy or Avastin at the discretion of the investigator. Safety was assessed by incidence of any adverse…

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Precision Knockdown Of EGFR Gene Express

Journal of Neuro-Oncology Background:  Electromagnetic fields (EMF) in the radio frequency energy (RFE) range can affect cells at the molecular level. Here we report a technology that can record the specific RFE signal of a given molecule, in this case the siRNA of epidermal growth factor receptor (EGFR). We demonstrate that cells exposed to this…


Nativis Voyager RFE Preclinical Studies at University of California San Diego-Moores Cancer Center

American Society of Clinical Oncology
2015 ASCO Annual Meeting
Abstract No: e13050
Citation: J Clin Oncol 33:5s, 2015 (suppl; abstr e13050)
Author(s): Rajesh Mukthavaram, Pengfei Jiang, Natsuko Nomura, Sandeep C. Pingle, John Butters, Bennett M Butters, Santosh Kesari; UC San Diego Moores Cancer Center, La Jolla, CA; UC San Diego, La Jolla, CA; Nativis, Seattle, WA; Nativis, Seattle, CA


Non-Thermal Radio Frequency Stimulation of Tubulin Polymerization in Vitro: A Potential Therapy for Cancer Treatment

Open Journal of Biophysics
Vol.04 No.04 (2014), Article ID: 51105, 21 pages
John T. Butters¹, Xavier A. Figueroa²*, Bennett Michael Butters¹
¹Nativis Inc., Seattle, WA, USA
²Sciencia Incognita Consulting, LLC, Seattle, WA, USA